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pentobarbital will lessen the extent or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May perhaps bring on loss of virologic r